By Edgar Haber
Issues lined comprise: X-ray crystallography of ligands. Catalytic antibodies. Nature of the antigen. Antibody binding websites. Maturation of the immune reaction. Computational biochemistry of antibodies and T-cell receptors. Antigen-specific T-cell receptors and their reactions. Key beneficial properties * X-Ray Crystallography of Ligands * Catalytic Antibodies * Nature of the Antigen * Antibody Binding websites * Maturtion of the Immune reaction * Computational Biochemistry of Antibodies and * T-Cell Receptors * Antigen-Specific T-Cell Receptors and Their Reactions
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Extra info for Antibodies and T-Cell Receptors,
1994). 6. High specificity of low affinity reactions: TCR on CD8+ CTL clone 2C distinguishes sharply between two naturally processed peptides, p2Ca and p2Ca-Y4, in association with the same syngeneic MHC-I protein, Kb. (Upper) Specific lysis of T2-Kb target cells by CTL 2C in the presence of various concentrations of p2Ca and p2Ca-Y4. , 1994). , 1994a). 37 38 HERMAN N. EISEN ET AL. The cross-reactions exhibited by T cells with sets of peptides having closely related or overlapping sequences, as in Fig.
5 and predicted by Eq. (3), over a wide range of affinity values ( Clo4 to about lo6 M-'), the log epitope density was a linear function of the log TCR affinity with a slope of -1. The fit suggests that in a T cell-target cell conjugate the extent of ligation of the T cell's TCR molecules by pepMHC complexes on the target cell can be described by a relationship in the form of the law of mass action (Fig. 5). The validity of this model should become evident when its predictive ability is put to the test: Since the product of epitope density and TCR affinity is constant (over the linear range shown in Fig.
1990a). , 1993). , 1995). , a reasonable next step will be to measure the abundance of these peptides in order to find out whether epitope densities commonly limit T-cell responses (Tsomides, 1995). E. TCR-PepMHC Engagement: An Afinity Model The intensity of the T-cell response has been widely assumed to be determined, in large measure, by TCR affinity for pepMHC complexes and the number of these complexes on target cells (epitope density). The preceding section dealt with epitope density; here we focus on TCR afinity.
Antibodies and T-Cell Receptors, by Edgar Haber