DAIDEN.IN Book Archive > Industrial Technical > Kenneth J. Olivier Jr., Sara A. Hurvitz's Antibody-Drug Conjugates: Fundamentals, Drug Development, PDF

Kenneth J. Olivier Jr., Sara A. Hurvitz's Antibody-Drug Conjugates: Fundamentals, Drug Development, PDF

By Kenneth J. Olivier Jr., Sara A. Hurvitz

ISBN-10: 1119060680

ISBN-13: 9781119060680

Providing useful and confirmed recommendations for antibody-drug conjugate (ADC) drug discovery luck in oncology, this e-book is helping readers increase the drug defense and healing efficacy of ADCs to kill precise tumor cells.

• Discusses the fundamentals, drug supply techniques, pharmacology and toxicology, and regulatory approval strategies
• Covers the behavior and layout of oncology medical trials and using ADCs for tumor imaging
• Includes case experiences of ADCs in oncology drug development
• Features contributions from highly-regarded specialists at the frontlines of ADC learn and development

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Extra info for Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

Example text

Blood 1982;59:1–11. Macek C Monoclonal antibodies: key to a revolution in clinical medicine. JAMA 1982;247:2463–70. xxxi xxxii Historical Perspective: What Makes Antibody–Drug Conjugates Revolutionary? 10 Goldenberg DM, Kim EE, DeLand FH, Bennett S, Primus FJ. 11 12 13 14 15 16 17 18 19 20 Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen. Cancer Research 1980;40:2984–92. Antibody‐guided irradiation of malignant lesions: three cases illustrating a new method of treatment.

The goal of combination chemotherapy, pioneered by Emil “Tom” Frei and others [1], was to increase antitumor efficacy of cytotoxic drug therapy, without substantially increasing overall toxicity to the patient, by using agents with nonoverlapping dose-limiting toxicities. However, such modalities have proven only partially effective at the maximum achievable doses, limited by the severe side effects of the cytotoxic agents used. Attaching cytotoxic effector molecules to an antibody to form an antibody–drug conjugate (ADC) provides a mechanism for the selective delivery of the cytotoxic payload to cancer cells via the specific binding of the antibody moiety to cancer-selective cell surface molecules.

5 for each conjugate (determined spectrophotometrically). (a) mAb1-SMCC-DM1; (b) mAb2-SPP-DM1; (c) mAb3-sulfo-SPDB-DM4. , Molecular Pharmaceutics, 12, 1738–1744, copyright 2015, American Chemical Society [55]. 1 Typical Antibody–Drug Conjugates DAR value itself during conjugation reactions could be sufficient to control the levels of nonmodified antibody in the defined ADC preparation [50]. Mass spectroscopy is also a useful tool to analyze chromatographic peptide maps in order to determine the actual conjugation sites in the antibody moiety of the ADC.

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Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer by Kenneth J. Olivier Jr., Sara A. Hurvitz


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